Defective polymorphonuclear leukocyte metabolism and function in canine cyclic neutropenia
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چکیده
منابع مشابه
Defective polymorphonuclear leukocyte metabolism and function in canine cyclic neutropenia.
Humans and grey collie dogs with cyclic neutropenia are known to suffer from an increased rate of bacterial infection. Because of the previously described microanatomic abnormalities of lysosome formation found in the polymorphonuclear leukocytes (PMNs) of dogs with canine cyclic neutropenia, studies of these cells were undertaken. PMNs from grey collie dogs were found to have significant metab...
متن کاملDefective Polymorphonuclear Leukocyte Formyl Peptide
Juvenile periodontitis (JP) is a disease characterized by severe gingival infections. PMN from some JP patients exhibit abnormal chemotactic responsiveness when challenged with the synthetic formyl peptide, FMLP. While investigating PMN function in JP, we found a patient in whom abnormal PMN chemotactic responses to FMLP were associated with a defective population of PMN formyl peptide receptor...
متن کاملHuman polymorphonuclear leukocyte function in urine.
Pyuria is usually present in patients with urinary tract infections. Therefore, it is surprising that the host defense function of polymorphonuclear leukocytes (PMNs) in urine is not well understood. Studies by Chernew and Braude demonstrated that urine suppressed PMN phagocytic function in an environment containing 7-8% serum (1). Similarly, studies by Norden, Green, and Kass suggested that PM...
متن کاملA comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia.
BACKGROUND AND OBJECTIVES Cyclic neutropenia (CyN) in childhood and severe congenital neutropenia (SCN) are congenital disorders that cause chronic neutropenia. Mutations in the neutrophil elastase gene, ELA2, have been reported in patients with CyN and in those with SCN. We examined granulopoietic defects in CyN patients with those in SCN patients. DESIGN AND METHODS Three patients with CyN ...
متن کاملModulation of polymorphonuclear leukocyte function by cetiedil.
Cetiedil citrate monohydrate inhibits sickling of red cells and aggregation of platelets. We assessed its ability to attenuate polymorphonuclear leukocyte (PMN) function. PMN aggregation in response to 2 X 10(-7) M formyl-met-leu-phe (FMLP) was inhibited in a dose-dependent fashion by cetiedil concentrations ranging from 60 to 250 microM. Additionally, 125 microM cetiedil inhibited PMN aggregat...
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ژورنال
عنوان ژورنال: Blood
سال: 1975
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v46.6.921.921